Fatty Acid and Lipotoxicity in Obesity and Diabetes
Novartis Foundation Symposium
1. Auflage November 2007
222 Seiten, Hardcover
Wiley & Sons Ltd
Kurzbeschreibung
Fatty Acid and Lipotoxicity in Obesity and Diabetes deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and beta-cell function and insulin resistance. Chapters deal with the molecular genetics and molecular physiology of energy homeostasis.
Metabolic diseases such as obesity, diabetes and hypertension are among the most common chronic illnesses and major causes of morbidity worldwide. These diseases are due to alterations of basic metabolic pathways such as those for glucose and lipids, and they are extremely costly to treat. Because of their
increasing prevalence they have attracted tremendous attention from the scientific community in recent years and significant advances have been made in our understanding of their molecular nature.
* The potential lipotoxic effect of accumulation of fatty acids in non-adipose issue is thought to be a major component in the development of insulin resistance.
* Chronic exposure to elevated free fatty acids affects pancreatic ß cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue.
* Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle.
This book presents an integrated approach to the problems of obesity and type 2 diabetes and carefully examines the role that fatty acids and lipids play in the development and progression of these diseases and in the transition from one to the other. Topics covered include lipid metabolism, adipose tissue biology, ß cell function and insulin resistance. Specific chapters also deal with the molecular genetics and molecular physiology of energy homeostasis. Fatty Acids and Lipotoxicity in Obesity and Diabetes will be of interest to anyone working on the causes of obesity and diabetes.
Bruce M. Spiegelman Transcriptional control of energy homeostasis through
the PGC1 coactivators
Discussion
Stephen O'Rahilly Human obesity and insulin resistance: lessons from
experiments of nature
Discussion
Deborah M. Muoio and Timothy R. Koves Lipid-induced metabolic
dysfunction in skeletal muscle
Discussion
Alan D. Attie, Matthew T. Flowers, Jessica B. Flowers, Albert K. Groen,
Folkert Kuipers and James M. Ntambi Stearoyl-CoA desaturase
deficiency, hypercholesterolaemia, cholestasis and diabetes
Discussion
Karen Reue The role of lipin 1 in adipogenesis and lipid metabolism
Discussion
David Carling The role of the AMP-activated protein kinase in the regulation
of energy homeostasis
Discussion
Gökhan S. Hotamisligil Endoplasmic reticulum stress and inflammation in
obesity and type 2 diabetes
Discussion
Ira Tabas, Tracie Seimon, Jerry Arellano, Yankun Li, Fabien Forcheron,
Dongying Cui, Seongah Han, Chien-Ping Liang, Alan Tall and
Domenico Accili The impact of insulin resistance on macrophage death
pathways in advanced atherosclerosis
Discussion
Sandra Lobo and David A. Bernlohr Fatty acid transport in adipocytes and
the development of insulin resistance
Discussion
Paul N. Black and Concetta C. DiRusso Vectorial acylation: linking fatty
acid transport and activation to metabolic trafficking
Discussion
Günther Daum, Andrea Wagner, Tibor Czabany, Karlheinz Grillitsch and
Karin Athenstaedt Lipid storage and mobilization pathways in yeast
Discussion
John Zhong Li and Peng Li Cide proteins and the development of
obesity
Discussion
General discussion I
Visualizing brown adipose tissue with FDG-PET
Takashi Kadowaki, Toshimasa Yamauchi, Naoto Kubota, Kazuo Hara and
Kohjiro Ueki Adiponectin and adiponectin receptors in obesity-linked
insulin resistance
Discussion
Gabriel Pascual, Amy L. Sullivan, Sumito Ogawa, Amir Gamliel,
Valentina Perissi, Michael G. Rosenfeld and Christopher K. Glass
Anti-inflammatory and antidiabetic roles of PPAR³
Discussion
Final discussion
Nutrition, ageing and lipotoxicity
Index of contributors
Subject index
