Natural Lactones and Lactams
Synthesis, Occurrence and Biological Activity
1. Auflage Oktober 2013
392 Seiten, Hardcover
4 Tabellen
Monographie
Kurzbeschreibung
Comprehensive in its coverage, this text fills the need for an up-to-date summary focusing on recently developed and improved synthetic methods for the preparation of the most important classes of lactones and lactams - all in one volume.
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Lactones and lactams, cyclic molecules found in nature, yet so versatile that they can be reused in both the pharmaceutical industry and as chiral building blocks in organic synthesis, are the focus of this book.
Although there a numerous tomes on heterocyclic compounds and natural products, this text fills the gap for an up-to-date summary of recently developed and improved synthetic methods for the preparation of the most important classes of lactones and lactams.
Each chapter deals with the general and most recent synthetic methods leading to a specific class of lactone or lactam to enable quick accessto the procedure you desire. With brief descriptions of the occurrence and biological or pharmaceutical activity of each compound class, the authors have ensured that this book is comprehensive in its coverage.
A valuable resource for organic, bio-, and medicinal chemists in academia and industry wanting to learn about successful synthetic routes to important natural products and use this as inspiration for their own work in the lab.
TETRONIC ACIDS
Introduction
Natural Occurrence, Biological Activities, and Biosynthesis
5-Ylidene Tetronic Natural Products
5-Monosubstituted Tetronic Natural Products
5-Disubstituted Tetronic Natural Products
5-Unsubstituted Tetronic Natural Products
Conclusions
RECENT ADVANCES IN THE FIELD OF NATURALLY OCCURRING 5,6-DIHYDROPYRAN-2-ONES
Introduction
Synthetic Methodologies for 5,6-Dihydropyran-2-ones
Formation of Stereogenic Centers inside the Dihydropyrone Ring
Pharmacological Properties of Pyrones
Biosynthetic Formation of Pyrones
Syntheses of Natural 5,6-Dihydropyran-2-ones Reported during the Period from 2006 to the First Half of 2012
BETA-LACTAMS
Introduction
Monocyclic Beta-Lactams
Penams
Cephalosporins
Clavulanic Acid
Carbapenems
Spiro-Fused Beta-Lactams
Summary
ALPHA-ALKYLIDENE-GAMMA- AND DELTA-LACTONES AND LACTAMS
Introduction
Occurrence, Biosynthesis, and Biological Activities of Alpha-Alkylidene Gamma- and Delta-Lactones and Lactams
Recent Advances in the Synthesis of Alpha-Alkylidene Gamma- and Delta-Lactones and Lactams
Conclusions
MEDIUM-SIZED LACTONES
Introduction
Total Synthesis of Eight-Membered Lactones
Total Synthesis of Nine-Membered Lactones
Conclusions
MACROLACTONES
Introduction
General Methods for the Synthesis of Macrolactones
Synthesis of Macrolides
Synthesis of Macrodiolides
Synthesis of Macrotriolides
Conclusions and Perspectives
RESORCYLIC ACID LACTONES
Introduction - A Historical Perspective
Biosynthesis
Chemical Synthesis
Conclusion and Outlook
CYCLIC PEPTIDES
Introduction
Synthesis of Natural Lactones and Lactams
Conclusion
Index
