Organic Conformational Analysis and Stereochemistry from Circular Dichroism Spectroscopy
Methods in Stereochemical Analysis
1. Auflage April 2000
496 Seiten, Hardcover
Wiley & Sons Ltd
Kurzbeschreibung
Unter Zirkulardichroismus (CD) versteht man die spezifisch unterschiedliche Absorption von links- und rechtszirkular polarisiertem Licht durch bestimmte Moleküle. CD-Effekte lassen sich in Abhängigkeit von der Wellenlänge messen und spektroskopisch auswerten; sie geben beispielsweise Auskunft über die Konformation organischer Verbindungen. Dieses Buch richtet sich an den organischen Chemiker, der mit den Grundprinzipien der Stereochemie vertraut ist, und erläutert die Anwendung der CD-Spektroskopie zur Konformationsanalyse ausführlich und verständlich. (06/00)
A unique guide to variable temperature CD spectroscopy and its application in organic chemistry
This timely, original, thought-provoking work looks at organic stereochemistry from the perspective of circular dichroism (CD), using variable temperature CD spectroscopy to determine the conformation or absolute configuration of chiral molecules. With an emphasis on the analysis of optically active ketones and the carbonyl chromophore, the authors demonstrate the advantages of this highly sensitive spectroscopic tool for obtaining stereochemical information in diverse areas of organic chemistry, biochemistry, and medicinal/pharmaceutical chemistry. They combine detailed examples of stereochemical analysis with clear, thorough presentations, correlating chiroptical data with molecular mechanics calculations as well as data from NMR spectroscopy and other spectroscopic techniques. In addition, they provide a systematic survey of the professional literature, featuring an extraordinary collection of original CD spectra run at varying temperatures. Coverage includes:
* Chiroptical measurements: CD and ORD (Optical Rotatory Dispersion)
* Conformational analysis of compounds ranging from simple cyclic ketones to polycyclics
* Conjugated and homoconjugated systems
* Stereochemistry of the carbon-carbon double bond
* Stereochemistry from exciton coupling of two or more chromophores
* An interesting historical account of the development of stereochemical concepts
Optical Activity.
The Octant Rule.
Conformational Analysis of Substituted Cyclohexanones.
Other Cycloalkanones.
Saturated Bicyclic Ketones.
Saturated Polycyclic Ketones.
Isotopically Perturbed Ketones.
Diketones.
Unsaturated and Cyclopropyl Ketones.
Dienes.
Biaryls and Helicenes.
Exciton Coupling and Exciton Chirality.
Indexes.
"It is a must for libraries and for all research groups engaged in experimental or theoretical work in this area." (Angewandte Chemie International Edition, Vol. 40 No. 9)
"...strongly recommended for research libraries serving organic and pharmaceutical chemists and...to some individuals working in those areas." (Journal of the American Chemical Society, Vol. 124, No. 12, 2002)
JEROME E. GURST, PhD, is Professor of Chemistry at the University of West Florida, Pensacola.
