Preparative Chromatography for Separation of Proteins
Wiley Series on Biotechnology
1. Auflage April 2017
608 Seiten, Hardcover
Wiley & Sons Ltd
Preparative Chromatography for Separation of Proteins addresses a wide range of modeling, techniques, strategies, and case studies of industrial separation of proteins and peptides.
* Covers broad aspects of preparative chromatography with a unique combination of academic and industrial perspectives
* Presents Combines modeling with compliantce useing of Quality-by-Design (QbD) approaches including modeling
* Features a variety of chromatographic case studies not readily accessible to the general public
* Represents an essential reference resource for academic, industrial, and pharmaceutical researchers
Series Preface
Preface
Chapter 1: Model Based Preparative Chromatography Process Development in the QbD Paradigm
A. Staby, S. Ahuja, A. Rathore
Chapter 2: Adsorption Isotherms: Fundamentals and Modelling Aspects
J.M. Mollerup
Chapter 3: Simulation of process chromatography
B. Nilsson, N. Andersson
Chapter 4: Simplified methods based on mechanistic models for understanding and designing chromatography processes for proteins and other biological products
N. Yoshimoto, S. Yamamoto
Chapter 5: Development of Continuous Capture Steps in Bioprocess Applications
F. Riske, T. Ransohoff
Chapter 6: Computational Modeling in Bioprocess Development
F. Insaidoo, S. Banerjee, D. Roush, S. Cramer
Chapter 7: Chromatographic scale up on a volume basis
E.B. Hansen
Chapter 8: Scaling up Industrial Protein Chromatography: Where Modeling Can Help
C. Antoniou, J. McCue, V. Natarajan, J. Thömmes, Q.S. Yuan
Chapter 9: High Throughput Process Development
S.M. Pirrung, M. Ottens
Chapter 10: High-throughput column chromatography performed on liquid handling stations - process characterization and error analysis
P. Diederich, J. Hubbuch
Chapter 11: Lab Scale Development of Chromatography Processes
H. Li, J. Pollard, N. Tugcu
Chapter 12: Problem solving by using modelling
M.P. Breil, S.S. Frederiksen, S. Kidal, T.B. Hansen
Chapter 13: Modeling Preparative Cation-Exchange Chromatography of Monoclonal Antibodies
S. Hunt, T. Larsen, R.J. Todd
Chapter 14: Model-Based Process Development in the Biopharmaceutical Industry
L. Sejergaard, H. Ahmadian, T.B. Hansen, A. Staby, E.B. Hansen
Chapter 15: Dynamic simulations as a predictive model for a Multicolumn Chromatography Separation
M. Bisschops, M Brower
Chapter 16: Chemometrics Applications in Process Chromatography
A.S. Rathore, S.K. Singh
Chapter 17: Mid-UV Protein Absorption Spectra and Partial Least Squares Regression as Screening and PAT Tool
S. Hansen, N. Brestrich, A. Staby, J. Hubbuch
Chapter 18: Recent Progress towards more Sustainable Biomanufacturing: Practical Considerations for Use in the Downstream Processing of Protein Products
M.T.W. Hearn
Index
ANURAG S. RATHORE is a Professor in the Department of Chemical Engineering at the Indian Institute of Technology, New Delhi, India. He has published several books that include Quality by Design for Biopharmaceuticals: Principles and Case Studies (Wiley, 2009).
SATINDER AHUJA is President of Ahuja Consulting, USA, and the author/editor of numerous books including Chiral Separation Methods for Pharmaceutical and Biotechnological Products (Wiley, 2010), Trace and Ultratrace Analysis by HPLC (Wiley, 1992), and Selectivity and Detectability Optimizations in HPLC (Wiley, 1989).
