Skeletal Development and Remodeling in Health, Disease and Aging, Volume 1068

Our understanding of how the skeleton is remodeled and repaired has
been enormously expanded in the past decade.



Using advanced molecular technologies including transgenesis,
gene knockout, and gene array, we are gaining a better
understanding of both the precise pathways through which
osteoblasts lay down new bone and how osteoclasts remove old bone.
These studies have not only helped us understand the basic
biological properties of the skeleton and how it responds to
hormonal, cytokine, and mechanical stimulation, but also, in some
instances, clarified the source of pathophysiology.

The eventual goal of such discoveries is to lay down a firm
scientific foundation for the identification of novel cellular and
molecular targets for future drug development. This volume presents
the significant headway that scientists have made in this
undertaking and the book is organized around four broad themes:
skeletal development and repair, molecular endocrinology of bone,
bone cell biology, and conservation of skeletal integrity. Also
included are papers that focus on current and emerging therapies
for osteoporosis.

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