Static Headspace-Gas Chromatography
Theory and Practice
2. Auflage Juni 2006
384 Seiten, Hardcover
Wiley & Sons Ltd
Kurzbeschreibung
Static headspace gas chromatography is a technique used for the concentration and analysis of volatile organic compounds. Useful in the analyses of alcohols in blood and residual solvents in pharmaceutical products, as well as the industrial analyses of monomers in polymers and plastics, flavor compounds in beverages and food products, and fragrances in perfumes and cosmetics, it enables the analyst to assay a variety of sample matrices, while avoiding the time-consuming and costly preparation involved with traditional GC. This book provides the most thorough and current treatment of static HS-GC.
The only reference to provide both current and thorough coverage of this important analytical technique
Static headspace-gas chromatography (HS-GC) is an indispensable technique for analyzing volatile organic compounds, enabling the analyst to assay a variety of sample matrices while avoiding the costly and time-consuming preparation involved with traditional GC.
Static Headspace-Gas Chromatography: Theory and Practice has long been the only reference to provide in-depth coverage of this method of analysis. The Second Edition has been thoroughly updated to reflect the most recent developments and practices, and also includes coverage of solid-phase microextraction (SPME) and the purge-and-trap technique. Chapters cover:
* Principles of static and dynamic headspace analysis, including the evolution of HS-GC methods and regulatory methods using static HS-GC
* Basic theory of headspace analysis-physicochemical relationships, sensitivity, and the principles of multiple headspace extraction
* HS-GC techniques-vials, cleaning, caps, sample volume, enrichment, and cryogenic techniques
* Sample handling
* Cryogenic HS-GC
* Method development in HS-GC
* Nonequilibrium static headspace analysis
* Determination of physicochemical functions such as vapor pressures, activity coefficients, and more
Comprehensive and focused, Static Headspace-Gas Chromatography, Second Edition provides an excellent resource to help the reader achieve optimal chromatographic results. Practical examples with original data help readers to master determinations in a wide variety of areas, such as forensic, environmental, pharmaceutical, and industrial applications.
Preface to the First Edition.
List of Acronyms and Symbols.
1. General introduction.
1.1 Principles of headspace analysis .
1.2 Types of headspace analysis.
1.3 The evolution of the HS-GC methods.
1.4 Headspace -- gas chromatography literature.
1.5 Regulatory methods utilizing (static) HS-GC.
1.6 References.
2. Theoretical background of HS-GC and its applications.
2.1 Basic theory of headspace analysis.
2.2 Basic physicochemical relationships.
2.3 Headspace sensitivity.
2.4 Headspace linearity.
2.5 Duplicate analyses.
2.6 Multiple headspace extraction (MHE).
2.7 References.
3. The technique of HS-GC.
3.1 Sample vials.
3.2 Caps.
3.3 Septa.
3.4 Thermostatting.
3.5 The fundamentals of headspace sampling systems.
3.6 Use of open-tubular (capillary) columns.
3.7 Enrichment techniques in HS-GC.
3.8 Special techniques with the balanced-pressure systems.
3.9. Reaction HS-GC.
3.10 References.
4. Sample handling in HS-GC.
4.1 Equilibration.
4.2 Solution approach.
4.3 Sample handling and sample introduction.
4.4 Preparation of standard solutions.
4.5 Influence of the matrix.
4.6 Methods aiming the complete evaporation of the analyte.
4.7 References.
5. Headspace methods for quantitative analysis.
5.1 Internal normalization.
5.2 Internal standard method.
5.3 External standard method.
5.4 Standard addition method.
5.5 Multiple headspace extraction (MHE).
5.6 Analysis of solid samples (adsorption systems).
5.7 Calibration techniques with headspace samples of varying volumes.
5.8 Analysis of gas samples.
5.9 References.
6. Method development in HS-GC.
6.1 General guidelines.
6.2 Determination of the residual monomer content of polystyrene pellets.
6.3 Determination of residual solvents in a printed plastic film.
6.4 Determination of the volatile constituents of a cathodic electrolytic plating bath.
7. Nonequilibrium static headspace analysis.
7.1 Accelerated analysis.
7.2 Heat-sensitive samples.
7.3 References.
8. Qualitative analysis by HS-GC.
8.1 The use of HS-GC in 'fingerprinting.'.
8.2 The use of headspace sampling in hyphenated systems.
8.3 The use of HS-GC in microbiology.
8.4 References.
9. Special measurements.
9.1 Determination of vapor pressures.
9.2 Determination of activity coefficients.
9.3 Determination of related physicochemical functions.
9.4 Determination of phase distribution (partition coefficient).
9.5 Reaction constant measurements.
9.6 Determination of solute solubility by MHE.
9.7 Gas-solid systems.
9.8 Validation of the headspace instrumentation: investigation of detector linearity and detection limit.
9.9 References.
Index.
Dr. LESLIE S. ETTRE was a senior scientist at Perkin-Elmer Corporation until his retirement in 1990. Between 1988 and 1995 he served as an adjunct professor in the Department of Chemical Engineering at Yale University, and from 1995 until 2004 he continued his association with the school as a research affiliate. In addition to lecturing widely in the field of gas chromatography, Dr. Ettre has published over 200 scientific and technical papers, and is the author and editor of numerous books, including Encyclopedia of Industrial Chemical Analysis. He has received numerous awards, including the National Award in Chromatography of the American Chemical Society and the AJP Martin Award of the Chromatographic Society--the highest honors in the United States and Europe, respectively.
