The Molecular Biology of Cancer
A Bridge from Bench to Bedside
2. Auflage April 2013
640 Seiten, Softcover
Lehrbuch
Kurzbeschreibung
This comprehensive text provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. Written by an international panel of researchers, specialists and practitioners in the field, the text discusses all aspects of cancer biology from the causes, development and diagnosis through to the treatment of cancer. The text offers in-depth coverage of traditional areas of study, while also discussing areas of controversy and emerging importance and highlighting future directions for research.
This comprehensive text provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. Written by an international panel of researchers, specialists and practitioners in the field, the text discusses all aspects of cancer biology from the causes, development and diagnosis through to the treatment of cancer. The text offers in-depth coverage of traditional areas of study, while also discussing areas of controversy and emerging importance and highlighting future directions for research.
Preface to the Second Edition, ix
Reviews of the First Edition, x
Acknowledgments and Dedication, xi
About the Companion Website, xii
Introduction, 1
1 Overview of Cancer Biology, 3
Michael Khan and Stella Pelengaris
2 The Burden of Cancer, 43
William P. Steward and Anne L. Thomas
3 Nature and Nurture in Oncogenesis, 67
Michael Khan and Stella Pelengaris
4 DNA Replication and the Cell Cycle, 111
Stella Pelengaris and Michael Khan
5 Growth Signaling Pathways and the New Era of Targeted Treatment of Cancer, 146
Stella Pelengaris and Michael Khan
6 Oncogenes, 188
Stella Pelengaris and Michael Khan
7 Tumor Suppressors, 239
Martine F. Roussel
8 Cell Death, 266
Stella Pelengaris and Michael Khan
9 Senescence, Telomeres, and Cancer Stem Cells, 295
Maria A. Blasco and Michael Khan
10 Genetic Instability, Chromosomes, and Repair, 314
Michael Khan
11 There Is More to Cancer than Genetics: Regulation of Gene and Protein Expression by Epigenetic Factors, Small Regulatory RNAs, and Protein Stability, 350
Stella Pelengaris and Michael Khan
12 Cell Adhesion in Cancer, 383
Charles H. Streuli
13 Tumor Immunity and Immunotherapy, 410
Cassian Yee
14 Tumor Angiogenesis, 429
Christiana Ruhrberg
15 Cancer Chemistry: Designing New Drugs for Cancer Treatment, 438
Ana M. Pizarro and Peter J. Sadler
16 Biologically Targeted Agents from Bench to Bedside, 461
Michael Khan, Peter Sadler, Ana M. Pizarro, and Stella Pelengaris
17 The Diagnosis of Cancer, 509
Anne L. Thomas, Bruno Morgan, and William P. Steward
18 Treatment of Cancer: Chemotherapy and Radiotherapy, 526
Anne L. Thomas, J.P. Sage, and William P. Steward
19 Caring for the Cancer Patient, 544
Nicky Rudd and Esther Waterhouse
20 Systems Biology of Cancer, 554
Walter Schubert, Norbert C.J. de Wit, and Peter Walden
Glossary, 585
Answers to Questions, 597
Index, 603
"This book will be invaluable for nursing and medical students, establishing a basic understanding and progressing to more complex issues. The end-of-chapter review questions are great preparation for exams." (Nursing Standard, 1 September 2013
Mike Khan Ph.D FRCP is Associate Professor of Medicine at University Hospitals of Coventry and Warwickshire and previous Head of Molecular Medicine at the University of Warwick.
