Barriers and Channels Formed by Tight Junction Proteins I, Volume 1257

Tight junctions between epithelial and endothelial cells form
selective barriers and paracellular channels and regulate
paracellular transport of solutes, immune cells, and drugs. More
specifically, tight junctions consist of proteins that laterally
interconnect neighboring cells of epithelia and endothelia. Certain
proteins seal the tight junction, so that a nearly impermeable
barrier develops, whereas others form channels that allow for
permeation between the cells. Recent investigations have focused on
tight junction proteins, belonging to the claudin family
(claudins-1 to -27 in humans) and the newly defined group of TAMP
(three proteins: occludin, Marvel-D2, and tricellulin).
Barriers and Channels Formed by Tight Junction Proteins I
showcases work in this area clustered around three major themes:
the molecular properties of tight junctions, for example, the role
of the claudin family of proteins and the formation of ion and
charge-selective channels; the regulation of tight junction and
barrier functions via genetic mechanisms and scaffold protein
mediation; and the functional role of the tight junction in various
tissues, such as the skin, lungs, endothelia, and nervous
system

NOTE: Annals volumes are available for sale as individual
books or as a journal. For informatio.n on institutional journal
subscriptions, please visit href="http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632">http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632.

ACADEMY MEMBERS: Please contact the New York Academy of Sciences
directly to place your order (www.nyas.org). Members of the New
York Academy of Science receive full-text access to the Annals
online and discounts on print volumes. Please visit
http://www.nyas.org/MemberCenter/Join.aspx for more information
about becoming a member.