Asymmetric Dearomatization Reactions

You, Shu-Li (Editor)

1. Edition August 2016
XX, 399 Pages, Hardcover
11 tables
Monograph

ISBN: 978-3-527-33851-1

Wiley-VCH, Weinheim

Wiley Online Library Content Sample Chapter Index

Short Description

This unique book describes the rapidly growing field of asymmetric dearomatization reactions with a focus on catalytic methods.

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The first comprehensive account of the rapidly growing field of asymmetric dearomatization reactions with a focus on catalytic methods.
It introduces the concept of dearomatization and describes recent progress in asymmetric reaction procedures with different catalyst systems, such as organocatalysts, transition metal catalysts, and enzymes. Chapters on dearomatizations of electron-deficient aromatic rings, dearomatization reactions via transition metal-catalyzed cross-couplings as well as dearomatization strategies in the synthesis of complex natural products are also included.
Written by pioneers in the field, this is a highly valuable source of information not only for professional synthetic chemists in academia and industry but also for all those are interested in asymmetric methodologies and organic synthesis in general.

1. Asymmetric Dearomatization with Chiral Auxiliaries and Reagents
2. Organocatalytic Asymmetric Transfer Hydrogenation of Aromatics
3. Transition-metal-catalyzed Asymmetric Hydrogenation of Aromatics
4. Asymmetric Reactions of Dearomatized Intermediates
5. Asymmetric Oxidative Dearomatization Reaction
6. Asymmetric Dearomatization via Cycloaddition Reaction
7. Organocatalytic Asymmetric Dearomatization Reactions
8. Transition-metal-catalyzed Allylic Dearomatization Reactions
9. Dearomatization via Transition Metal-catalyzed Cross-Coupling Reactions
10. Dearomatization Reactions of Electron-Deficient Aromatic Rings
11. Asymmetric Dearomatization under Enzymatic Conditions
12. Dearomatization Strategies in the Synthesis of Complex Natural Products
13. Miscellaneous Asymmetric Dearomatization Reactions

Shu-Li You is a professor at the State Key Laboratory of Organometallic Chemistry at the Shanghai Institute of Organic Chemistry (SIOC). He received his BSc in chemistry from Nankai University, Tianjin, China, in 1996 and obtained his PhD from SIOC in 2001 under the supervision of Prof. Li-Xin Dai. He then did postdoctoral studies with Prof. Jeffery W. Kelly at The Scripps Research Institute, La Jolla, California. He worked at the Genomics Institute of the Novartis Research Foundation as a Principal Investigator from 2004 before returning to SIOC in 2006.
He has published over 170 peer-reviewed papers, 5 book chapters, and filed over 30 Chinese patents as a co-inventor. He is the recipient of many awards, e.g. the Chinese Chemical Society (CCS)-Wiley Young Chemist Award (2007), Thieme Chemistry Journals Award (2010), The National Science Fund for Distinguished Young Scholars (2010), AstraZeneca Excellence in Chemistry Award (2011), CAS Teaching Excellence Award (2012, 2013, 2014), Roche Chinese Young Investigator Award (2014), WuXi PharmaTech Life Science and Chemistry Award (2014), and RSC Merck Award (2015). His research interests mainly focus on enantioselective direct C-H bond functionalization and catalytic asymmetric dearomatization (CADA) reactions.

S.-L. You, Shanghai Institute of Organic Chemistry, P.R. China