Microwaves in Organic and Medicinal Chemistry
Methods and Principles in Medicinal Chemistry (Series Nr. 25)
1. Edition June 2005
XII, 410 Pages, Hardcover
62 Pictures (1 Colored Figures)
16 tables
Monograph
ISBN:
978-3-527-31210-8
Wiley-VCH, Weinheim
Short Description
A handy guide for organic and medicinal chemists focusing on common reaction types in medicinal chemistry, including solid-phase and combinatorial methods. Microwave theory, latest developments in instrumentation and a variety of examples from the recent literature are included.
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Further versions
The authors of this guide are experts on the use of microwaves for drug synthesis as well as having much experience in teaching courses held under the auspices of the American Chemical Society and the IUPAC.
In this handy source of information for any practicing synthetic chemist they focus on common reaction types in medicinal chemistry, including solid-phase and combinatorial methods. They consider the underlying theory, latest developments in microwave applications and include a variety of examples from recent literature, as well as less common applications that are equally relevant for organic and medicinal chemists.
An indispensable reference for researchers with an affinity to modern methods.
Introduction: Microwave Synthesis in Perspective
MICROWAVE THEORY
Microwave Radiation
Microwave Dielectric Heating
Microwave versus Conventional Thermal Heating
Microwave Effects
EQUIPMENT REVIEW
Domestic Microwave Ovens
Microwave Reactors for Organic Synthesis
Multimode Instruments
Single-Mode Instruments
MICROWAVE PROCESSING TECNIQUES
Solvent-free Reactions
Phase-Transfer Catalysis
Reactions Using Solvents
Parallel Processing
Scale-Up in Batch and Continuous Flow
GETTING STARTED WITH MICROWAVE CHEMISTRY
Why Use Microwave Reactors?
Translating Convenionally Heated Methods
Reaction Optimization and Library Generation
Limitations and Safety Aspects
LITERATURE SURVEY: GENERAL ORGANIC SYNTHESIS
Transition Metal-catalyzed Carbon-Carbon Bond Formation
Transition Metal-catalyzed Carbon-Heteroatom Bond Formation
Other Transition Metal-mediated Processes
Heterocycle Synthesis
LITERATURE SURVEY: COMBINATORIAL AND HIGH-THROUGHPUT SYNTHESIS
Solid-Phase Organic Synthesis
Soluble Polymer-supported Synthesis
Task-specific Ionic Liquids
Fluorous Synthesis
Polymer-supported Reagents, Catalysts and Scavengers
MICROWAVE THEORY
Microwave Radiation
Microwave Dielectric Heating
Microwave versus Conventional Thermal Heating
Microwave Effects
EQUIPMENT REVIEW
Domestic Microwave Ovens
Microwave Reactors for Organic Synthesis
Multimode Instruments
Single-Mode Instruments
MICROWAVE PROCESSING TECNIQUES
Solvent-free Reactions
Phase-Transfer Catalysis
Reactions Using Solvents
Parallel Processing
Scale-Up in Batch and Continuous Flow
GETTING STARTED WITH MICROWAVE CHEMISTRY
Why Use Microwave Reactors?
Translating Convenionally Heated Methods
Reaction Optimization and Library Generation
Limitations and Safety Aspects
LITERATURE SURVEY: GENERAL ORGANIC SYNTHESIS
Transition Metal-catalyzed Carbon-Carbon Bond Formation
Transition Metal-catalyzed Carbon-Heteroatom Bond Formation
Other Transition Metal-mediated Processes
Heterocycle Synthesis
LITERATURE SURVEY: COMBINATORIAL AND HIGH-THROUGHPUT SYNTHESIS
Solid-Phase Organic Synthesis
Soluble Polymer-supported Synthesis
Task-specific Ionic Liquids
Fluorous Synthesis
Polymer-supported Reagents, Catalysts and Scavengers
"This is a well thought out and nicely constructed book which has been carefully written with its audience in mind. It is more than just a literature review, it is a handbook of "how to do it", which will be extremely useful to the practitioner. In my view, this is now the seminal text for chemists (especially, but not exclusively, medicinal chemists) using microwaves on laboratory scale. I can warmly recommend this book, and would expect it to end up on the shelves in most synthetic organic laboratories."
Organic Process Research & Development
"...this easy to read work is essential for chemists wishing to learn about the state of the art in microwave-assisted organic synthesis chemistry and will be a handy reference volume for more experienced microwave chemists." ChemMedChem
"This eight-chapter monograph provides a broad overview of the area with sufficient detail to guide the inexperienced user and enough breadth to satisfy the experienced organic and medical chemist. This well-written book can be viewed as consisting of three parts: background/theory, reagents/equipment, and literature overview. (...) Overall, the text is very well written. The references are very current, and the 'how to' sections are clear. This book definitely speaks to its audiences at just the right levels for each. (...) There is a lot of very practical information in this book to recommend it for inclusion in both industrial and academic libraries." Journal of Medicinal Chemistry
"...Microwaves in organic and medicinal chemistry provides a superb reference tool for any interested chemist using, or thinking of using, microwave assisted organic synthesis on an occasional or regular basis. The text is clear, well-written and gives an authoritative discussion of the field. It misses little in the way of technical or chemical detail ... For the beginner or a microwave regular, this book provides an excellent outline of the state of play in this field. ....this is the place to look...a very enjoyable and interesting book, revealing that no question is too silly to ask."
Chemistry World
"The book is very well laid out and presented. The schemes are excellent and the photographs very clearly reproduced. The index is well put together and it is easy to find specific reactions. In summary, this book is general enough to be useful to chemists new to the field as well as proving a valuable resource to those who already use microwave heating in their chemistry, and I certainly recommend it to both."
Angewandte Chemie IE
"In summary, this monograph is well-written by experts in the field. Since all chapters are written by the same authors, redundant recurrences are omitted and helpful cross links are supplied. The book is logically organized and easy to read. While the experienced user will find many interesting hints, details and references, the beginner will profit from vivid explanations and practical advice. As an invaluable source of information for every chemist interested in microwave assisted organic chemistry, the book is recommended to the library of every chemistry department." Archiv der Pharmazie
"This book is an indispensable information source for organic and medicinal chemists in academia, as well as those in the chemical and the pharmaceutical industry. It provides the reader a well-structured, up-to-date, and exhaustive overview of known synthetic procedures involving the use of microwave technology. Some chapters of this book are sufficiently convincing as to encourage scientists not only to use microwave synthesis in their research, but also to offer training for their students and co-workers." Carbohydrate Polymers
"...this book contains many pertinent examples for chemists working in distinct areas such as discovery research or process development."
CHOICE
Organic Process Research & Development
"...this easy to read work is essential for chemists wishing to learn about the state of the art in microwave-assisted organic synthesis chemistry and will be a handy reference volume for more experienced microwave chemists." ChemMedChem
"This eight-chapter monograph provides a broad overview of the area with sufficient detail to guide the inexperienced user and enough breadth to satisfy the experienced organic and medical chemist. This well-written book can be viewed as consisting of three parts: background/theory, reagents/equipment, and literature overview. (...) Overall, the text is very well written. The references are very current, and the 'how to' sections are clear. This book definitely speaks to its audiences at just the right levels for each. (...) There is a lot of very practical information in this book to recommend it for inclusion in both industrial and academic libraries." Journal of Medicinal Chemistry
"...Microwaves in organic and medicinal chemistry provides a superb reference tool for any interested chemist using, or thinking of using, microwave assisted organic synthesis on an occasional or regular basis. The text is clear, well-written and gives an authoritative discussion of the field. It misses little in the way of technical or chemical detail ... For the beginner or a microwave regular, this book provides an excellent outline of the state of play in this field. ....this is the place to look...a very enjoyable and interesting book, revealing that no question is too silly to ask."
Chemistry World
"The book is very well laid out and presented. The schemes are excellent and the photographs very clearly reproduced. The index is well put together and it is easy to find specific reactions. In summary, this book is general enough to be useful to chemists new to the field as well as proving a valuable resource to those who already use microwave heating in their chemistry, and I certainly recommend it to both."
Angewandte Chemie IE
"In summary, this monograph is well-written by experts in the field. Since all chapters are written by the same authors, redundant recurrences are omitted and helpful cross links are supplied. The book is logically organized and easy to read. While the experienced user will find many interesting hints, details and references, the beginner will profit from vivid explanations and practical advice. As an invaluable source of information for every chemist interested in microwave assisted organic chemistry, the book is recommended to the library of every chemistry department." Archiv der Pharmazie
"This book is an indispensable information source for organic and medicinal chemists in academia, as well as those in the chemical and the pharmaceutical industry. It provides the reader a well-structured, up-to-date, and exhaustive overview of known synthetic procedures involving the use of microwave technology. Some chapters of this book are sufficiently convincing as to encourage scientists not only to use microwave synthesis in their research, but also to offer training for their students and co-workers." Carbohydrate Polymers
"...this book contains many pertinent examples for chemists working in distinct areas such as discovery research or process development."
CHOICE
C. Oliver Kappe was born in Graz (Austria) and received his doctoral degree from the Karl-Franzens-University in Graz in 1992, working with Gert Kollenz on acylketenes. After postdoctoral research work with Curt Wentrup at the University of Queensland, Brisbane (Australia), and with Albert Padwa at Emory University, Atlanta (USA), he moved back to the University of Graz where he currently holds a position as associate Professor. In 2003 he spent a sabbatical at the Scripps Research Institute in La Jolla (USA) with K. Barry Sharpless. His research focuses on microwave-enhanced synthesis, combinatorial chemistry, multicomponent reactions, and biologically active heterocycles.
Alexander Stadler was born in Bruck and der Mur (Austria) and studied Chemistry at the University of Graz. He then obtained his doctoral degree for studies on microwave-accelerated reactions in solution and on solid phase in the group of C. Oliver Kappe. After postdoctoral research work on microwave-assisted transition metal-catalyzed coupling reactions in the group of Mats Larhed at the University of Uppsala (Sweden) he joined Anton Paar GmbH in Graz in 2004 as product specialist for microwave synthesis.
Alexander Stadler was born in Bruck and der Mur (Austria) and studied Chemistry at the University of Graz. He then obtained his doctoral degree for studies on microwave-accelerated reactions in solution and on solid phase in the group of C. Oliver Kappe. After postdoctoral research work on microwave-assisted transition metal-catalyzed coupling reactions in the group of Mats Larhed at the University of Uppsala (Sweden) he joined Anton Paar GmbH in Graz in 2004 as product specialist for microwave synthesis.
