Macrocycles
Construction, Chemistry and Nanotechnology Applications
March 2011
608 Pages, Hardcover
Wiley & Sons Ltd
Macrocyclic molecules contain rings made up of seven or more atoms.
They are interesting because they provide building blocks for
synthesizing precise two or three dimensional structures - an
important goal in nanotechnology. For example, they can be used to
develop nanosized reaction vessels, cages, switches and shuttles,
and have potential as components in molecular computers. They also
have applications as catalysts and sensors.
Macrocycles: Construction, Chemistry and
Nanotechnology Applications is an essential
introduction this important class of molecules and describes how to
synthesise them, their chemistry, how they can be used as
nanotechnology building blocks, and their applications. A wide
range of structures synthesised over the past few decades are
covered, from the simpler cyclophanes and multi-ring aromatic
structures to vases, bowls, cages and more complex multi-ring
systems and 3D architectures such as "pumpkins",
interlocking chains and knots. Topics covered include:
* principles of macrocycle synthesis
* simple ring compounds
* multi-ring aromatic structures
* porphyrins and phthalocanines
* cyclophanes
* crown ethers, cryptands and spherands
* calixarenes, resorcinarenes, cavitands, carcerands, and
heterocalixarenes
* cyclodextrins
* cucurbiturils
* cyclotriveratylenes
* rotaxanes
* catenanes
* complex 3D architectures, including trefoils and knots
Macrocycles: Construction, Chemistry and
Nanotechnology Applications distills the essence of
this important topic for undergraduate and postgraduate students,
and for researchers in other fields interested in getting a general
insight into this increasingly important class of molecules.
1 Introduction.
1.1 Simple Ring Compounds.
1.2 Three-Dimensional Aliphatic Carbon Structures.
1.3 Annulenes.
1.4 Multi-Ring Aromatic Structures.
1.5 Porpyrins and Phthalocanines.
1.6 Conclusions.
References.
2 Cyclophanes.
2.1 Introduction.
2.2 Cyclophanes with One Aromatic System and AliphaticChain.
2.3 Cyclophanes with More than One Aromatic Ring.
2.4 Napthalenophanes and Other Aromatic Systems.
2.5 Cyclophanes Containing Heteroaromatic Systems.
2.6 Ferrocenophanes.
2.7 Conclusions.
Bibliography.
References.
3 Crown Ethers, Cryptands and Other Compounds.
3.1 Introduction.
3.2 Crown Ethers.
3.3 Simple Complexes with Crown Ethers.
3.4 Azacrowns, Cyclens and Cyclams.
3.5 Crowns Containing Other Heteroatoms.
3.6 Lariat and Bibracchial Crown Ethers.
3.7 Cryptands.
3.8 Spherands.
3.9 Combined and Multiple Systems.
3.10 Applications of Crown Ethers and Related Compounds.
3.11 Conclusions.
Bibliography.
References.
4 Calixarenes.
4.1 Introduction.
4.2 History.
4.3 Structures of Calixarenes.
4.4 Chemical Modification of Calixarenes.
4.5 Complexes with Calixarenes.
4.6 Bis and Multicalixarenes.
4.7 Oxacalixarenes, Azacalixarenes and Thiacalixarenes.
4.8 Resorcinarenes: Synthesis and Structure.
4.9 Cavitands and Carcerands.
4.10 Conclusions.
Bibliography.
References.
5 Heterocalixarenes and Calixnaphthalenes.
5.1 Introduction.
5.2 Calixnaphthalenes.
5.3 Tropolone-Based Macrocycles.
5.4 Calixfurans.
5.5 Calixpyrroles.
5.6 Calixindoles, Calixpyridines and Calixthiophenes.
5.7 Conclusions.
Bibliography.
References.
6 Cyclodextrins.
6.1 Introduction.
6.2 Complex Formation by Cyclodextrins.
6.3 Cyclodextrins of Other Sizes.
6.4 Modification Reactions of Cyclodextrins.
6.5 Selectivity of Cyclodextrins.
6.6 Multiple Cyclodextrin Systems.
6.7 Polymeric Cyclodextrins.
6.8 Cyclodextrins Combined with Other Macrocyclic Systems.
6.9 Therapeutic Uses of Cyclodextrins.
6.10 Other Uses of Cyclodextrins.
6.11 Conclusions.
Bibliography.
References.
7 Cyclotriveratylenes and Cryptophanes.
7.1 Introduction.
7.2 Synthesis of Cyclotriveratrylenes.
7.3 Modification of Cyclotriveratrylenes.
7.4 Synthesis of Optically Active Cyclotriveratrylenes.
7.5 Modification of the Bridging Groups.
7.6 Modification of the Aromatic Rings with OrganometallicGroups.
7.7 Selective Binding Applications of Cyclotriveratrylenes.
7.8 Analogues of CTV.
7.9 Synthesis and Structure of Cryptophanes.
7.10 Modification of Cryptophanes.
7.11 Complexes with Cryptophanes.
7.12 Cryptophane-Xenon Complexes.
7.13 Other Uses of Cryptophanes.
7.14 Hemicryptophanes.
7.15 Conclusions.
Bibliography.
References.
8 Cucurbiturils.
8.1 Introduction.
8.2 Complexation Behaviour of Simple Cucurbiturils.
8.3 Modification of Cucurbiturils.
8.4 Uses of Cucurbiturils.
8.5 Hemicucurbiturils.
8.6 Conclusions.
Bibliography.
References.
9 Rotaxanes and Catenanes.
9.1 Introduction.
9.2 Rotaxanes.
9.3 Catenanes.
9.4 Conclusions.
Bibliography.
References.
10 Other Supramolecular Systems, Molecular Motors, Machinesand Nanotechnological Applications.
10.1 Introduction.
10.2 Other Molecular Systems.
10.3 Molecular Devices, Motors and Machines.
10.4 Conclusions.
Bibliography.
References.
Index.
Applications distils the essence of this important topic for
undergraduate and postgraduate students, and for researchers in
other fields who are interested in getting a general insight into
this increasingly important class of molecules."
(Chimie Nouvelle, 1 March 2013)
Cranfield University, UK
Dr Davis is a research fellow at Cranfield University, specialising
in the biochemical and supramolecular aspects of electrochemistry.
As well as pursuing academic research he has undertaken contract
research for organisations such as Unilever Research (Port
Sunlight), ITM Power Ltd (Sheffield), Timestrip (Hitchen) and
DEFRA, and spent a 4-year research post within Gillette UK
Professor Séamus Higson
Cranfield University, UK
Séamus Higson is Professor of Bio- and Electro-Analysis at
Cranfield University which he joined in August 2002. His previous
career spans academic departments of chemistry, medicine and
materials science and this is reflected in his research. Professor
Higson also serves within an advisory and / or consultative
capacity for a number of public bodies and also acts as Technical
Director for Microarray Ltd - a company formed upon science and
patents originating from his group. His current research is
primarily focussed towards practical implementation of electro
analytical science and analytical biochemistry for biomedical,
environmental and industrial process control applications.
