Circular Dichroism
Principles and Applications
2. Edition May 2000
912 Pages, Hardcover
Wiley & Sons Ltd
Short Description
Circular dichroism (CD) is observed when optically active molecules absorb left- and right-hand circular polarized light slightly differently. It is measured with a CD spectropolarimeter, which measures small differences in left-handed and right-handed absorbances as a function of wavelength in the far UV (at wavelengths down to 190-170 nm.) The analysis of CD spectra can yield valuable information about secondary structure of biological macromolecules.
Multidisciplinary coverage of circular dichroism's principles, applications, and latest advances
The four years since the publication of the first edition of Circular Dichroism: Principles and Applications have seen a rapid expansion of the field, including new applications, improved understanding of principles, and a growing interest in circular dichroism (CD) among researchers from a wide variety of disciplines. The Second Edition keeps pace with this phenomenal growth with up-to-date contributions from dozens of the world's leading researchers and practitioners in chirality, chemistry, biochemistry, and analytical chemistry, as well as vibrational and luminescence spectroscopy.
With nine entirely new chapters and substantial updates of existing material, Circular Dichroism, Second Edition provides important insight into the immense potential of CD and bridges the gap between theory and practice. The book begins with coverage of historical developments and moves quickly to fascinating reports on recent advances and emerging new fields in CD. New and updated coverage includes:
* VOA theory
* Solid-state CD applications
* Fast time-resolved CD measurements
* A model illustrating how polymers amplify chirality
* Induced CD of polymers
* CD of nucleic acids: nonclassical conformations and modified oligonucleotides
* DNA-drug and DNA-protein interactions
* Applications of CD to important pharmaceutical compounds
Featuring an increased emphasis on biological molecules and extensive applications to organic stereochemistry and biopolymers, Circular Dichroism: Principles and Applications, Second Edition will prove a valuable and frequently consulted reference for organic chemists, biochemists, and medicinal and pharmaceutical chemists.
Circular Dichroism: An Introduction (G. Snatzke).
From Pasteur to Parity Nonconservation: Theories of the Origin of Molecular Chirality (S. Mason).
Theoretical Approach to Electronic Optical Activity (A. Koslowski, et al.).
Vibrational Optical Acivity Theory (L. Nafie & T. Freedman).
Fast Time-Resolved Circular Dichroism Measurements (D. Kliger & J. Lewis).
The Octant Rule (D. Lightner).
Circular Dichroism and Chirality of Dienes (J. Gawroski).
Exciton Chirality Method: Principles and Applications (N. Berova & K. Nakanishi).
A Model for How Polymers Amplify Chirality (M. Green).
Induced CD or Polymers (E. Yashima & Y. Okamoto).
Application of CD to the Study of Some Cholesteric Mesophase (G. Gottarelli & G. Spada).
Circular Dichroism of Inorganic Complexes: Interpretation and Applications (R. Kuroda).
Circular Dichroism of Peptides and Proteins (N. Sreerama & R. Woody).
Peptide and Protein Conformational Studies with Vibrational Circular Dichroism and Related Spectroscopies (T. Keiderling).
HPLC-CD: Stereochemical Analysis at Work (P. Salvadori, et al.).
Applications of Chiroptical Spectroscopy in the Characterization of Compounds Having Pharmaceutical Importance (H. Brittain).
Index.
"I wholeheartedly recommend this book to all who are interested in chirality. For medicinal and synthetic chemists working with chiral substances...this is a very useful reference book." (Journal of Medicinal Chemistry, Vol. 44, No. 7, 2001)
"...this book will make a valuable addition to the libraries of the cognoscenti..." (Analytical Biochemistry, Vol. 294, 2001)
"...this book serves as an excellent resource for information regarding circular dichroism." (Pharmaceutical Research, Vol. 18, No. 4, April 2001)
"This excellent book provides the reader with a snapshot of contemporary research on CD and related topics. It should be of great value to a wide variety of chemists and biochemists." (Journal of the American Chemical Society, Vol. 124, 2002)
KOJI NAKANISHI, PhD, is Centennial Professor of Chemistry in the Department of Chemistry at Columbia University, New York. He is the recipient of many international awards and the Person of Cultural Merit Award (Japanese government).
ROBERT W. WOODY, PhD, is a Professor in the Department of Biochemistry and Molecular Biology at Colorado State University, Fort Co
