Cancer Signaling
From Molecular Biology to Targeted Therapy
1. Edition October 2016
XXX, 324 Pages, Softcover
178 Pictures (150 Colored Figures)
25 tables
Textbook
Short Description
This text focuses on the essentials in molecular oncology. In particular, signaling pathways that affect a different types of cancers are covered in detail. The textbook is written in an easily accessible style and includes 32 educational videos.
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Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it.
The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells. In contrast to the complexity of its topic, the text is easy to read. 32 specially prepared teaching videos on key concepts and pathways in cancer signaling are available online for users of the print edition and have been integrated into the text in the enhanced e-book edition.
Tumor Cell Heterogeneity and Resistance to Targeted Therapy
Cell Cycle of Tumor Cells
Cell Aging and Cell Death
Growth Factors and Receptor Tyrosine Kinases
The Philadelphia Chromosome and BCR-ABL1
MAPK Signaling
PI3K-AKT-mTOR Signaling
Hypoxia-Inducible Factor (HIF)
NF-kappaB Pathways
Wnt Signaling
Notch Signaling
Hedgehog Signaling
TGFbeta Signaling
Carol Stocking is Head of the Research Group Retroviral Pathogenesis at the Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology in Hamburg, Germany. She is a highly regarded expert in the field of leukemogenesis and hematology. Her areas of research are gene regulation, molecular control of differentiation, and hematopoietic stem cells. Dr. Stocking has authored more than 120 original publications in top international journals and 20 book chapters.
Oliver Müller is Professor for Applied Life Sciences at the University for Applied Sciences Kaiserslautern, Germany. He holds academic degrees in both biochemistry and medicine. His areas of research are the intracellular signal transduction and the genes and proteins involved in carcinogenesis. Professor Müller is author of more than 80 original articles, 11 patents, 15 scientific reviews and 4 book chapters. His work was honoured by several science awards.
