Methodologies in Amine Synthesis
Challenges and Applications
1. Edition February 2021
480 Pages, Hardcover
437 Pictures (111 Colored Figures)
Handbook/Reference Book
Short Description
This unique book summarizes state-of-the-art synthetic methodologies for the efficient preparation of amines as well as their application in pharmaceutical chemistry and materials science.
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Provides a unique overview of efficient synthetic routes to one of the most important compound classes in organic and pharmaceutical chemistry!
Amines are among the most important compounds in organic chemistry due to their wide occurrence in natural products, drugs, crop protection compounds, and advanced materials. For example, the majority of drugs are amines or contain functional groups derived from amines. Powerful and efficient methods for the introduction of the amino group are therefore of great importance to synthetic chemists in academia and industry.
Methodologies in Amine Synthesis ? Challenges and Applications presents powerful and state-of-the-art methods for the efficient preparation of amines. It summarizes recent advances in the electrophilic amination reaction, hydroamination, C?H amination as well as newly developed photocatalytic approaches. It further describes organocatalytic and enzymatic routes to the generation of amines under mild and environmentally friendly conditions. In addition, it highlights the relevance of the amino function in bioactive molecules, drugs, and in the engineering of smart materials. Finally, the application of palladium-catalyzed aromatic amination in industrial context is critically discussed.
* Only up-to-date and comprehensive book on the preparation of amines ? one of the most frequently occurring compound classes found in natural products, bioactive molecules, and advanced materials.
* Presents efficient and useful synthetic methods, highlights opportunities/ challenges as well as applications in pharmaceutical chemistry and materials science.
* Chapters are compiled by well-known experts in the field. One of them edited the previous books ?Modern Amination Methods? (2001) and ?Amino Group Chemistry? (2007).
The book Methodologies in Amine Synthesis ? Challenges and Applications is a musthave for chemists in academia and industry working in the field of organic synthesis and catalysis, natural product chemistry, drug synthesis and pharmaceutical chemistry, as well as materials science.
Remote Functionalizations Using Nitrogen Radicals in H-Atom Transfer (HAT) Reactions
Radical-based C-N bonds formation in photo/electro-chemistry
Propargylamines: recent advances in asymmetric synthesis and use as chemical tools in organic chemistry
Transition metal-catalyzed chiral amines synthesis
Industrial Relevance of Asymmetric Organocatalysis in the Preparation of Chiral Amine Derivatives
Biocatalytic Synthesis of Chiral Amines Using Oxidoreductases
Engineering Functional Nanomaterials through the Amino Group
Recent advances in the synthesis of nitrogen compounds from biomass derivatives
Recent Advances in Synthesis of Arylamines in the Light of Application in Pharmaceutical and Chemical Industry
Luca Bernardi is Associate Professor at the Department of Industrial Chemistry "Toso Montanari" at Bologna University, Italy. He is co-author of about 80 articles, two patents and four book chapters. He received the "Thieme Journal Prize" in 2009 and the Ciamician Medal of the Organic Chemistry Division in 2010. His research is mainly directed at the development of new catalytic enantioselective reactions.
