Modern Aldol Reactions

Mahrwald, Rainer (Editor)

1. Edition June 2004
XX, 679 Pages, Hardcover
467 Pictures
94 tables
Handbook/Reference Book

ISBN: 978-3-527-30714-2

Wiley-VCH, Weinheim

Short Description

The complete spectrum of the aldol reaction is presented in this two-volume handbook. Top authors cover the fundamentals before moving on to enolates and catalytic reactions. Further sections are devoted to enzymatic as well as related reactions.
A comprehensive overview of this important topic, removing the need for time-consuming research among the widely dispersed literature.
With a foreword by Professor D. A. Evans.

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At long last, the complete spectrum of the aldol reaction is presented here in this two-volume handbook. Top authors guarantee contributions of the highest quality, beginning with fundamentals and then moving on to enolates and catalytic aldol reactions, including the Mukaiyama Reaction. Further sections are devoted to enzymatic aldol reactions in synthesis as well as such related reactions as the Henry, Ene and Aldol-Tishchenko reactions.

The wealth of information contained here allows a comprehensive overview of this important topic in organic chemistry, removing the need for the hitherto time-consuming research among the widely dispersed literature.

With a foreword by Professor D. A. Evans.

Fundamentals and Transition State Models
The Development of Titanium Enolate Based Aldol Reactions
Boron and Silicon Enolates in Crossed Aldol Reaction
Silver, Gold and Palladium Lewis-Acids
Boron and Silicon Lewis Acids for Mukaiyama Aldol Reactions
Copper Lewis Acids
Tin-promoted Aldol Reactions and Their Applications to Total Syntheses of Natural Products
Zirconium Alkoxides as Lewis Acids
Direct Catalytic Asymmetric Aldol Reaction Using Chiral Metal Complexes
Catalytic Enantioselective Aldol Additions with Chiral Lewis Bases
Amine-Catalyzed Aldol Reactions
Enzyme Catalyzed Aldol Additions
Antibody-Catalyzed Aldol Reactions
The Aldol-Tishchenko Reaction
The Aldol Reaction in Natural Product Synthesis: The Epothilone
Story

"This two-volume work is very rewarding reading, and can be strongly recommended for everyone who is seriously engaged in using modern aldol reactions - especially for diastereo- and enantioselectivity - or intends to enter the field. The editor and authors have achieved a well-balanced mixture of fundamentals and detailed description of methods and applications."
Angewandte Chemie IE

"This set will be a valuable addition to the library of researchers in the field and for graduate-level students."
CHOICE

"This two-volume set provides much needed comprehensive coverage of modern aldol reactions, an area of tremendous current activity, interest, and importance."
Journal of the American Chemical Society

"I recommend it highly to all students and research workers interestes in synthetic organic chemistry, and conclude that it is a "must-have" publication for all libraries serving a synthetic research community."
Applied Organometallic Chemistry

"...a most useful addition to any collection serving researchers and students in synthetic organic chemistry, or pharmacologists and others ..."
E-STREAMS

Born in 1950, Rainer Mahrwald studied chemistry at MLU Halle and subsequently joined the "Manfred von Ardenne" Research Institute in Dresden, where he led the synthetics group. He gained his doctorate under G. Wagner in Leipzig in 1979, and went on to the Institute of Organic Chemistry at the Academy of Science in Berlin, where he remained until 1990. Following a stay at the Philipps-University in Marburg, Dr. Mahrwald qualified as a lecturer at the Humboldt University Berlin, where he is now a private lecturer.

R. Mahrwald, Department of Organic Chemistry, Humboldt University, Berlin, Germany