Modern Fluoroorganic Chemistry

Synthesis, Reactivity, Applications

Kirsch, Peer

1. Edition July 2004
XII, 308 Pages, Hardcover
351 Pictures (15 Colored Figures)
22 tables
Handbook/Reference Book

ISBN: 978-3-527-30691-6

Wiley-VCH, Weinheim

Short Description

Die Chemie von fluororganischen Verbindungen ist aufregend, ungewöhnlich, aber nicht mehr exotisch - und von jedem Labor mit Standardausrüstung zu bewältigen. Diesen seinen Standpunkt untermauert der Autor dieses Bandes mit zahlreichen gut nachvollziehbaren Synthesevorschriften und Versuchsanleitungen, ergänzt durch Informationen zu Anwendungen fluorhaltiger Substanzen in Flüssigkristallen oder Polymeren. Eine lange erwartete Publikation, unentbehrlich für einschlägig interessierte Synthesechemiker.

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Further versions

In this handbook, Peer Kirsch clearly shows that this exciting field is no longer an exotic area of research. Aimed primarily at synthetic chemists wanting to gain a deeper understanding of the fascinating implications of including the highly unusual element fluorine in organic compounds, the main part of the book presents a wide range of synthetic methodologies and the experimental procedures selected undeniably show that this can be done with standard laboratory equipment. To round off, the author looks at fluorous chemistry and the applications of organofluorine compounds in liquid crystals, polymers and more besides.
This long-awaited book represents an indispensable source of high quality information for everyone working in the field.

INTRODUCTION
Why Organofluorine Chemistry
History
The Basic Materials
The Unique Properties of Organofluorine Compounds
Application of Organofluorine Compounds
SYNTHESIS OF COMPLEX ORGANOFLUORINE COMPOUNDS
Analytics of Organofluorine Compounds
Introduction of Fluorine
Perfluoroalkylation
Special Fluorinated Groups
Syntheses with Fluorinated Building Blocks
FLUOROUS CHEMISTRY
Fluorous Biphasic Catalysis
Fluorous Synthesis and Combinatorial Chemistry
FLUOROPHARMACEUTICALS
Why Fluorinated Pharmaceuticals?
Lipophilicity
Hydrogen bonding and Electrostatic Interactions
Metabolic Stabilization
Bioisosteric Mimicking
Orthogonal Reactivity and Suicide Inhibition
LIQUID CRYSTALS FOR ACTIVE MATRIX LCDs
Calamatic Liquid Crystals: A Short Introduction
Functioning of an Active Matrix LCD
Why Fluorinated Liquid Crystals?
Fluorinated Polar Groups
Fluorinated Bridge Structures
REFERENCES

"... a well-produced book with attractive graphics, photos and schemes. Throughout the book, coloured electrostatic maps of small organofluorine compounds are used to illustrate charge distributions. These are effective as well as attractive. I would point any organic chemist to this book who wants to learn about and do some fluorine chemistry. It provides uncluttered descriptions and a clear orientation to the literature in this important area of the organic chemistry."
CHEMBIOCHEM - A European Journal of Chemical Biology

Peer Kirsch received his PhD under the supervision of Prof. Staab at the Max Planck Insitute for Medical Research in Heidelberg. He joined the Liquid Crystal Division of Merck KGaA in 1995 and his research interest is the application of fluorine chemistry for the design and synthesis of liquid crystals.

P. Kirsch, Merck KGaA, Liquid Crystals Division, Darmstadt, Germany