Multi-Step Organic Synthesis

A Guide Through Experiments

Bogliotti, Nicolas / Moumné, Roba

1. Edition October 2017
XVI, 265 Pages, Softcover
433 Pictures
Textbook

ISBN: 978-3-527-34065-1

Wiley-VCH, Weinheim

Content Sample Chapter Index Instructor's Resources

Short Description

Combining theoretical knowledge, practical considerations as well as structural elucidation, this textbook presents 16 independent exercises based on published research articles to inspire students by way of having to solve real-life problems in chemistry.

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Further versions

Combining theoretical knowledge of synthetic transformations, practical considerations, structural elucidation by interpretation of spectroscopic data as well as rationalization of structure-property relations, this textbook presents a series of 16 independent exercises, including detailed descriptions of experimental procedures, questions, and answers. The experimental descriptions are very helpful for guiding less experienced students towards a better understanding of practical aspects in synthetic organic chemistry, while the broad scope of the questions and answers is excellent for learning purposes. The exercises are based on published research articles, adapted for didactic purposes, and will thus inspire students by way of having to solve real-life problems in chemistry.
A must-have for MSc and PhD students as well as postdocs in organic chemistry and related disciplines, and lecturers and organizers of lab courses in organic chemistry.

Preface
1) Atovaquone: An Antipneumocystic Agent
2) SEN794: A SMO Receptor Antagonist
3) Synthesis of a H1-H3 Antagonist
4) Synthesis of Eletriptan
5) Total Synthesis and Structure Revision of Streptophenazine A
6) Synthesis of Leiodermatolide: A Biologically Active Macrolide
7) Azobenzene-Thiourea Catalysts for the Control of Chemical Reactivity with Light
8) Synthesis and Properties of a Photo-activatable Mimic of Pyridoxal 5'-Phosphate
9) Fluorescent Peptides for Monitoring Activity of Autophagy-Initiating Enzyme
10) Fluorescent Peptide Probes for Cathepsin B
11) Total Synthesis of Stemoamide
12) Total Synthesis and Structure Revision of Caraphenol B
13) Synthetic Routes Towards Muricatacin and Analogs
14) Asymmetric Synthesis of (-)-Martinellic Acid
15) Cyclic Pseudopeptides as Potent Integrin Antagonists
16) Enantioselective Synthesis of Nonnatural Amno Acids for Incorporation in Antimicrobial Peptides
Further Reading

Nicolas Bogliotti is Assistant Professor at École normale supérieure Paris-Saclay, France. After his undergraduate studies at Université Nice Sophia-Antipolis, France, he obtained his MSc and PhD Degrees at Université Pierre et Marie Curie in Paris, France. He was a postdoc at ETH Zürich, Switzerland and Institut Curie, France, before his current position. His research interests focus on the synthesis of photosensitive molecules allowing visualization of recognition events, induction of a biological response and modulation of chemical reactivity.

Roba Moumné is Assistant Professor at Université Pierre et Marie Curie, France. She studied chemistry and completed her MSc and PhD at the same university. Before her current position, she was also a postdoctoral fellow at Max-Planck-Institut in Mülheim and der Ruhr, Germany, at University of Zürich, Switzerland and at Université Paris Descartes, France. Her research interests include bioorganic chemistry and peptide synthesis.